As I primarily use Linux and I had to find an alternative way to program radios like Tait, Icom etc that have Dos based software to program them along with the need to have a serial port. Well after some trial and errors with various emulators like dosemu and wine, I found dosbox was able to do what I need to accomplish with accessing the radio via USB to Serial cable which you can buy cheap enough off of eBay.
Edit dosbox config file:
$ nano .dosbox/dosbox-0.74.conf
and alter the ‘serial 1‘ line to read:
Then you can run your dos program in terminal:
$ dosbox /location/to/you/dos/program.exe